2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150700
    RLX-33 2784577-71-3 99.79%
    RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome.
    RLX-33
  • HY-15258A
    Lesinurad sodium 1151516-14-1
    Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
    Lesinurad sodium
  • HY-163316
    SIRT4-IN-1
    SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms.
    SIRT4-IN-1
  • HY-B0093A
    Benazepril hydrochloride 86541-74-4 99.96%
    Benazepril (CGS14824A) hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor to reduce angiotensin-II production. Benazepril hydrochloride inhibits oxidative stress and inhibits apoptosis by the PI3K/Akt signaling pathway. In addition, Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria. Benazepril hydrochloride can be used in the study of hypertension, heart failure and diabetic nephropathy.
    Benazepril hydrochloride
  • HY-B1402B
    Hydrocortisone hemisuccinate sodium 125-04-2 99.66%
    Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC).
    Hydrocortisone hemisuccinate sodium
  • HY-B1777A
    Spermine tetrahydrochloride 306-67-2 ≥98.0%
    Spermine tetrahydrochloride is an endogenous metabolite.
    Spermine tetrahydrochloride
  • HY-N0390R
    L-Glutamine (standard) 56-85-9
    L-Glutamine (Standard) is the analytical standard of L-Glutamine. This product is intended for research and analytical applications. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine (standard)
  • HY-N0415S
    Trigonelline-d3 chloride 99.41%
    Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
    Trigonelline-d3 chloride
  • HY-P3016A
    Glutamate oxaloacetate aminotransferase, porcine heart 9000-97-9
    Glutamate oxaloacetate aminotransferase, porcine heart catalyzes the reversible reaction of L-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate.
    Glutamate oxaloacetate aminotransferase, porcine heart
  • HY-100530C
    Sp-cAMPS sodium salt 142439-95-0 99.45%
    Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM.
    Sp-cAMPS sodium salt
  • HY-112868B
    ABH hydrochloride 194656-75-2
    ABH (hydrochloride) is an orally active arginase inhibitor (Ki = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis.
    ABH hydrochloride
  • HY-113371S
    2-Methylcitric acid-d3 146764-58-1 ≥98.0%
    2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
    2-Methylcitric acid-d3
  • HY-113437A
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium 169051-60-9 ≥98.0%
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite. It is used in the generation of micelles, liposomes, and artificial membranes.
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium
  • HY-132606A
    Nedosiran sodium 2247026-22-6
    Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate.
    Nedosiran sodium
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium 33068-19-8 ≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-N0729S2
    Linoleic acid-13C18 287111-25-5
    Linoleic acid-13C18 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].
    Linoleic acid-13C18
  • HY-W004661
    1,4-Dioxane-2,5-diol 23147-58-2 ≥98.0%
    1,4-Dioxane-2,5-diol is an endogenous metabolite.
    1,4-Dioxane-2,5-diol
  • HY-W009216
    2'-Deoxycytidine-5'-monophosphoric acid 1032-65-1 99.95%
    2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphoric acid
  • HY-W010697
    Cholesteryl linoleate 604-33-1 ≥98.0%
    Cholesteryl linoleate is shown to be the major cholesteryl ester contained in LDL and atherosclerotic lesions.
    Cholesteryl linoleate
  • HY-W011142
    2'-Deoxyuridine 5'-monophosphate disodium 42155-08-8 ≥98.0%
    2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.
    2'-Deoxyuridine 5'-monophosphate disodium
Cat. No. Product Name / Synonyms Application Reactivity